Reviews Chapters & Editorials


  • Madabhushi R, Pan L, Tsai LH. DNA Damage and its links to neurodegeneration. Neuron. 2014 July 16. doi: 10.1016/j.neuron.2014.06.034


  • Wang W, Kwon EJ, Tsai LH. MicroRNAs in learning, memory, and neurological diseases. Learn Mem. 2012 Aug 16;19(9):359-68. doi: 10.1101/lm.026492.112. (PMC Journal- In Process).
  • Su SC, Tsai LH. DNA methylation in cognition comes of age. Nat Neurosci. 2012 Jul 26;15(8):1061-2. doi: 10.1038/nn.3169. (PMC Journal- In Process).
  • Mungenast AE, Tsai LH. Cognitive Function in Health and Disease: The Role of Epigenetic Mechanisms. Neurodegener Dis. 2012;10(1-4):191-4.



  • Mungenast AE, Tsai L-H (2011) Addressing the complex etiology of Alzheimer’s disease: the role of p25/Cdk5. Future Neurology 6:481-496. (In Press) (PMC Journal- In Process).
  • Su SC, Tsai LH. Cyclin-Dependent Kinases in Brain Development and Disease. Annu Rev Cell Dev Biol. 2011 Nov 10;27:465-91 (PMC Journal- In Process).
  • Haggarty SJ, Tsai LH. Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem. 2011 Jul;96(1):41-52. PMCID: PMC3188418.
  • De Anda FC, Tsai LH.Axon selection: From a polarized cytoplasm to a migrating neuron. Commun Integr Biol. 2011 May;4(3):304-7. PMCID: PMC3187892.
  • Gräff J, Kim D, Dobbin MM, Tsai L-H. Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiological Review 2011 Apr;91(2):603-49. (PMC Journal- In Process).
  • Marín O, Valiente M, Ge X, Tsai LH. Guiding neuronal cell migrations. Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a001834. PMCID: PMC2828271.
  • Gräff J, Tsai LH.  Cognitive Enhancement: A molecular memory booster.  Nature. 2011 Jan 27; 469:474-475. (PMC Journal- In Process).



  • Fischer A, Sananbenesi F, Mungenast A, Tsai LH. Targeting the correct HDAC(s) to treat cognitive disorders. Trends Pharmacol Sci. 2010 Dec;31(12):605-17. (PMC Journal- In Process).
  • Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai L-H.  Amyloid-independent mechanisms in Alzheimer’s disease pathogenesis.  J Neurosci. 2010 Nov 10;30(45):14946-54.  (PMC Journal- In Process).
  • Singh K, Tsai L-H.  MicroTUB(B3)ules and Brain Development. Cell, 2010, Jan; 140: 7-9. Marín O, Valiente M, Ge X, Tsai LH.  Guiding neuronal cell migrations.  Cold Spring Harb Perspect Biol.  2010 Feb; 2(2):a001834. PMCID: PMC2828271



  • Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ.  Cyclin-dependent kinsases: a family portrait.  Nat Cell Biol. 2009 Nov;11(11):1275-6. PMCID: PMC2914104
  • Kim D, Tsai L-H.  Linking cell cycle reentry and DNA damage in neurodegeneration.  Ann NY Acad Sci. 2009 Jul;1170:674-9. (PMC Journal- In Process).
  • Kim D, Tsai L-H.  Bridging physiology and pathology in AD.  Cell. 2009, 137: 997-1000. (PMC Journal- In Process).
  • Frank CL, Tsai L-H.  Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity.  Neuron. 2009 May 14, 62(3): 312-326.  PMCID: PMC2757047



  • Fischer A, Tsai L-H. Cyclin dependent kinase 5 (Cdk5): linking synaptic plasticity and neurodegeneration. In Cyclin dependent kinase 5 (Cdk5). Eds. Nancy Ip, & Li-Huei Tsai, Springer Science and Business Media LLC, New York, 2008; 261-282.
  • Buchman JJ, Tsai L-H. Putting a notch in our understanding of nuclear migration.  Cell.  2008, 134: 912-4.
  • Samuels BA, Tsai L-H. Neuronal motility and structure: Cdk5 pathways.  In Larry R. Squire, Editor-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford, 2008.



  • Buchman JJ, Tsai L-H.  Spindle regulation in neural precursors of flies and mammals.  Nat Rev Neurosci. 2007, 8: 89-100.
  • Ayala R, Shu T, Tsai L-H.  Trekking across the brain: the journey of neuronal migration.  Cell 2007; 128: 29-43.



  • Xie Z, Samuels BA, Tsai L-H.  Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling—a hypothesis on neuronal migration.  Cereb Cortex.  2006: Suppl 1: i64-8.



  • Tsai L-H, Gleeson JG.  Nucleokinesis in neuronal migration.  Neuron 2005; 46: 383-388.



  • Samuels BA, Tsai L-H.  Nucleokinesis illuminated.  Nat Neurosci 2004; 7:1169-1170.
  • Cruz JC, Tsai L-H.  Cdk5 deregulation in the pathogenesis of Alzheimer’s disease.  Trends Mol Med.  2004; 10: 452-8.
  • Cruz JC, Tsai L-H.  A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease.  Curr Opin Neurobiol. 2004; 14: 390-394.
  • Tsai L-H, Lee MS, Cruz JC.  Cdk5, a therapeutic target for Alzheimer’s disease?  Biochim Biophys Acta.  2004; 1697: 137-142.
  • Xie Z, Tsai L-H.  Cdk5 phosphorylation of FAK regulates centrosome-associated microtubules and neuronal migration.  Cell Cycle.  2004; 3: 108-110.



  • Gupta A, Tsai L-H. Cyclin-dependent kinase 5 and neuronal migration in the neocortex. Neurosignals. 2003 Sep-Oct;12(4-5):173-9.
  • Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai LH. Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. J Neurosci. 2003 Apr 1;23(7):2769-78.
  • Samuels BA, Tsai L-H.  Cdk5 is a dynamo at the synapse.  Nat Cell Biol. 2003; 5: 689-690.
  • Lee, M-S, Tsai L-H.  Cdk5:  One of the links between senile plaques and neurofibrillary tangles? J Alzh Dis. 2003; 5:127-137.



  • Gupta A, Tsai L-H, Wynshaw-Boris A.  Life is a journey: a genetic look at neocortical development. Nat. Rev Gene, 2002; 3:342-55.
  • Patzke H, Tsai L-H.  Cdk5 sinks into ALS.  Trends Neurosci. 2002; 25:8-10.
  • Smith DS, Tsai L-H.  Cdk5 behind the wheel: a role in trafficking and transport.  Trends Cell Biol 2002; 12: 28-36.



  • Dhavan R, Tsai L-H.  A decade of Cdk5.  Nat Rev Mol Cell Biol. 2001; 2: 749-759.
  • Smith DS, Greer PL, Tsai L-H.  Cdk5 on the brain.  Cell Growth Differ 2001;12:277-283.
  • Gupta A, Tsai L-H.  A kinase to dampen the effects of cocaine?  Science 2001;292:236-237.
  • Lee M-S, Tsai L-H.  Cdk5 at the junction.  News and Views, Nat Neurosci 2001; 4: pp340-342.



  • Nikolic M, Tsai L-H.  Activity and regulation of p35/Cdk5 kinase complex. Methods Enzymol. 2000;325:200-13.
  • Kwon YT, Tsai L-H.  The role of the p35/Cdk5 kinase in cortical development. Results Probl Cell Differ. 2000;30:241-53.



  • Tsai L-H.  Stuck on the ECM. Trends Cell Biol. 1998 Jul;8(7):292-5.



  • Caviness VS Jr, Takahashi T, Miyama S, Tsai L-H.  Cytogenesis in the developing mouse neocortex. In: Brain lesions in the newborn.  Alfred Benzon Symposium 1994;37:25-42.



  • Stillman and J. Watson (eds), Cold Spring Harbor Laboratory Press.  Faha B, Meyerson M, Tsai L-H. Adenovirus E1A targets one of two cyclin A-kinase complexes.  Pezcoller Foundation Symposium 1992; 3:107-30.



  • Meyerson M, Faha B, Su LK, Harlow E, Tsai L-H. The cyclin-dependent kinase family.  In The Cell Cycle, Cold Spring Harbor Symposium on Quantitation Biology, 1991 56:177-186. D. Beach, B.