• Dileep V, Tsai L-H. Three-dimensional chromatin organization in brain function and dysfunction. Curr Opin Neurobiol. 2021 Jun 7;69:214-221. doi: 10.1016/j.conb.2021.04.006. E-published ahead of print.
  • Dileep V, Tsai L-H. Neuronal enhancers get a break. Neuron. 2021 June 2; 109 (11):1766-1768. doi: 10.1016/j.neuron.2021.05.008.
  • Chan D, Suk H-J, Jackson B, Milman N, Stark D, Beach SD, Tsai L-H. Induction of specific brain oscillations may restore neural circuits and be used for the treatment of Alzheimer’s disease. J Intern Med. Epub 2021 June 22. https://doi.org/10.1111/joim.13329.
  • Akay, LA, Effenberger AH, Tsai L-H. Cell of all trades: Oligodendrocyte precursor cells in synaptic, vascular, and immune function. Genes Dev. 2021 Feb 1; 35:180-198. doi:10.1101/gad.344218.120. PMID: 33526585.


  • Penney J, Ralvenius WT & Tsai, L-H. Modeling Alzheimer’s disease with iPSC-derived brain cells. Mol Psychiatry. 2020 Jan;25(1):148-167. Epub 2019 Aug 7. doi: 10.1038/s41380-019-0468-3. PMID: 31391546.


  • Adaikkan, C. & Tsai, L.-H., Gamma Entrainment: Impact on Neurocircuits, Glia, and Therapeutic Opportunities, Trends in Neurosciences, December 10, 2019, doi: 10.1016/j.tins.2019.11.001.
  • Pao P, Penney Jay, Tsai, L-H. Examining the Role of HDAC’s in DNA Double-Strand Break Repair in Neurons. Methods Molecular Biology, 2019; 1983: 225-234. doi: 10. 1007/978-1-4939-9434-2_13.
  • Raju R, Tsai, L-H. The complexity of neuroinflammation of single-cell resolution. Nature Reviews Neurology. 2019 March 11. http://doi.org/10.1038/s41582-019-0165-5.


  • Penney J, Tsai LH. Senescence mediates neurodegeneration. . 2018 September. 1-2. Doi: 10.1038/d41586-018-06677-7
  • Mathys H, Penney J, Tsai LH. A developmental switch in Microglial HDAC function. Immunity, 2018
    Mar 20; 48 (3): 476-478. Doi: 10.1016/j.immuni.2018.03.010. PMID: 2952197.


  • Watson LA, Tsai L-H. Molecular biology: Local metabolites linked to memory. Nature. 2017 Jun 15; 546(7658): 361-362. doi: 10.1038/nature22498. PMID: 28562586.
  • Barker SJ, Tsai L-H. MethyLock: DNA demethylation is the epigenetic key to axon regeneration. Neuron. 2017 Apr 19; 94(2): 221-223. doi: 10.1016/j.neuron.2017.04.006. PMID: 28426953.


  • Watson A, Tsai L-H. In the loop: Chromatin topology links genome structure to function in mechanisms underlying learning and memory. Curr Opin Neurobiol. 23 Dec; doi: 10.1016.conb.2016.12.002. PMID: 28024185.
  • Cholewa-Waclaw J, Bird A, von Schimmelmann M, Schaefer A, Yu H, Song H, Madabhushi R, Tsai L-H. The role of epigenetics mechanisms in the regulation of gene expressions in the nervous system. J Neurosci. 2016 Nov 9; 39(45): 11427-11434. doi: 10.1523/neurosci.2492-16.2016. PMID: 27911745
  • Canter RG, Penney J, Tsai L-H. The road to restoring neural circuits for the treatment of Alzheimer’s disease. Nature. 2016 Nov 9; 539 (7268): 187-196. doi: 10/1038/nature20412. PMID: 27830780.
  • Rudenko A, Tsai L-H. The hippocampus grows up. Nat Neurosci. 2016 Aug 26; 19(9): 1190-1. doi: 10.1038/nn.4368. PMID: 27571198.
  • Mungenast AE, Siegert S, Tsai L-H. Modeling Alzheimer’s disease using human induced pluripotent stem (iPS) cells. Mol Cell Neurosci. 2016 Jun; 73: 13-31. doi: 10.1016/j.mcn.2015.11.010. PMID: 26657644
  • Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai L-H, Tsien RW, Fishell G, Mullins C, Goncalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsaki G, Stevens C. What is memory? The present state of the engram. BMC Biol. 2016 May 19; 14 (1): 40. doi: 10.1186/s12915-016-0261-6. PMID: 27197636.
  • Anggono V, Tsai L-H, Gotz J. Glutamate Receptors in Alzheiemr’s Disease: Mechanisms and Therapies. Neural Plast. 2016 May 16; 2016: 8256196. Doi: 10.1155/2016/8256196. Epub 2016 May 16. PMID: 27293907.
  • Tsai LH, Siegert S. How MicroRNA’s are involved in Splitting the Mind. JAMA Psychiatry. 2016 April; 73 (4): 409-10. doi: 10.1001/jamapsichiatry.2015.3144. PMID: 26963490.


  • Penney J, Tsai L-H. JAKMIP1: Translating the Message for Social Behavior. Neuron. 2015 Dec 16;88(6): 1070-2. doi: 10.1016/j.neuron.2015.12.003. PMID: 26687214.


  • Penney J, Tsai L-H. Histone deacetylases in memory and cognition. Science Signaling. 2014 Dec 9; 7(335): re12. doi: 10.1126/scisignal.aaa0069. PMID: 25492968.
  • Alberini CM, Josselyn S. Tsai L-H. Editorial. Molecular and Cellular Cognition Society (MCCS) meetings. Neurobiol Learn Mem. 2014 Nov; 115:1-2. doi: 10.1016/j.nlm.2014.09.003. PMID: 25438252.
  • Pan L, Penney J, Tsai L-H. Chromatin regulation of DNA damage repair and genome integrity in the central nervous system. Mol Biol. 2014 Oct 9; doi: 10.1016/j.jmb.2014.08.001. PMID: 25128619.
  • Tsai L-H, Gräff J. On the resilience of remote traumatic memories against exposure therapy-mediated attenuation. EMBO. 2014 Aug 12. doi:10.15252/embr.201438913. PMID:20527989.
  • Madabhushi R, Pan L, Tsai LH. DNA Damage and its links to neurodegeneration. Neuron. 2014 July 16. doi: 10.1016/j.neuron.2014.06.034
  • Durak O, Tsai L-H. Human induced pluripotent stem cells: Now open to discovery. Cell Stem Cell. 2014 Jul 3; 15(1): 4-6. doi:10.1016/j.stem.2014.06.014. PMID: 24996162.
  • Seo J, Tsai L-H. Neuronal differentiation: 5-HT6R can do it alone. Nat Chem Biol. 2014 Jun 17: 488-9. Doi: 10.1038/nchembio. 1557. PMID: 24937065.
  • Rudenko A, Tsai L-H. Epigenetic modifications in the nervous system and their impact upon cognitive impairments. Neuropharmacology. 2014 May; 80: 70-82. doi: 10.1016/j.neuropharm.2014.01.043. PMID:24495398.


  • Tsai L-H, Madabhushi R. Alzheimer’s disease: A protective factor for the ageing brain. 2014 Mar 27; 507(7493): 439-40. doi: 10.1038/nature13214. PMID: 24670758.


  • Wang W, Kwon EJ, Tsai LH. MicroRNAs in learning, memory, and neurological diseases. Learn Mem. 2012 Aug 16;19(9):359-68. doi: 10.1101/lm.026492.112. (PMC Journal- In Process).
  • Su SC, Tsai LH. DNA methylation in cognition comes of age. Nat Neurosci. 2012 Jul 26;15(8):1061-2. doi: 10.1038/nn.3169. (PMC Journal- In Process).
  • Mungenast AE, Tsai LH. Cognitive Function in Health and Disease: The Role of Epigenetic Mechanisms. Neurodegener Dis. 2012;10(1-4):191-4.



  • Mungenast AE, Tsai L-H (2011) Addressing the complex etiology of Alzheimer’s disease: the role of p25/Cdk5. Future Neurology 6:481-496. (In Press) (PMC Journal- In Process).
  • Su SC, Tsai LH. Cyclin-Dependent Kinases in Brain Development and Disease. Annu Rev Cell Dev Biol. 2011 Nov 10;27:465-91 (PMC Journal- In Process).
  • Haggarty SJ, Tsai LH. Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem. 2011 Jul;96(1):41-52. PMCID: PMC3188418.
  • De Anda FC, Tsai LH.Axon selection: From a polarized cytoplasm to a migrating neuron. Commun Integr Biol. 2011 May;4(3):304-7. PMCID: PMC3187892.
  • Gräff J, Kim D, Dobbin MM, Tsai L-H. Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiological Review 2011 Apr;91(2):603-49. (PMC Journal- In Process).
  • Marín O, Valiente M, Ge X, Tsai LH. Guiding neuronal cell migrations. Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a001834. PMCID: PMC2828271.
  • Gräff J, Tsai LH.  Cognitive Enhancement: A molecular memory booster.  Nature. 2011 Jan 27; 469:474-475. (PMC Journal- In Process).



  • Fischer A, Sananbenesi F, Mungenast A, Tsai LH. Targeting the correct HDAC(s) to treat cognitive disorders. Trends Pharmacol Sci. 2010 Dec;31(12):605-17. (PMC Journal- In Process).
  • Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai L-H.  Amyloid-independent mechanisms in Alzheimer’s disease pathogenesis.  J Neurosci. 2010 Nov 10;30(45):14946-54.  (PMC Journal- In Process).
  • Singh K, Tsai L-H.  MicroTUB(B3)ules and Brain Development. Cell, 2010, Jan; 140: 7-9. Marín O, Valiente M, Ge X, Tsai LH.  Guiding neuronal cell migrations.  Cold Spring Harb Perspect Biol.  2010 Feb; 2(2):a001834. PMCID: PMC2828271



  • Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ.  Cyclin-dependent kinsases: a family portrait.  Nat Cell Biol. 2009 Nov;11(11):1275-6. PMCID: PMC2914104
  • Kim D, Tsai L-H.  Linking cell cycle reentry and DNA damage in neurodegeneration.  Ann NY Acad Sci. 2009 Jul;1170:674-9. (PMC Journal- In Process).
  • Kim D, Tsai L-H.  Bridging physiology and pathology in AD.  Cell. 2009, 137: 997-1000. (PMC Journal- In Process).
  • Frank CL, Tsai L-H.  Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity.  Neuron. 2009 May 14, 62(3): 312-326.  PMCID: PMC2757047



  • Fischer A, Tsai L-H. Cyclin dependent kinase 5 (Cdk5): linking synaptic plasticity and neurodegeneration. In Cyclin dependent kinase 5 (Cdk5). Eds. Nancy Ip, & Li-Huei Tsai, Springer Science and Business Media LLC, New York, 2008; 261-282.
  • Buchman JJ, Tsai L-H. Putting a notch in our understanding of nuclear migration.  Cell.  2008, 134: 912-4.
  • Samuels BA, Tsai L-H. Neuronal motility and structure: Cdk5 pathways.  In Larry R. Squire, Editor-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford, 2008.



  • Buchman JJ, Tsai L-H.  Spindle regulation in neural precursors of flies and mammals.  Nat Rev Neurosci. 2007, 8: 89-100.
  • Ayala R, Shu T, Tsai L-H.  Trekking across the brain: the journey of neuronal migration.  Cell 2007; 128: 29-43.



  • Xie Z, Samuels BA, Tsai L-H.  Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling—a hypothesis on neuronal migration.  Cereb Cortex.  2006: Suppl 1: i64-8.



  • Tsai L-H, Gleeson JG.  Nucleokinesis in neuronal migration.  Neuron 2005; 46: 383-388.



  • Samuels BA, Tsai L-H.  Nucleokinesis illuminated.  Nat Neurosci 2004; 7:1169-1170.
  • Cruz JC, Tsai L-H.  Cdk5 deregulation in the pathogenesis of Alzheimer’s disease.  Trends Mol Med.  2004; 10: 452-8.
  • Cruz JC, Tsai L-H.  A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease.  Curr Opin Neurobiol. 2004; 14: 390-394.
  • Tsai L-H, Lee MS, Cruz JC.  Cdk5, a therapeutic target for Alzheimer’s disease?  Biochim Biophys Acta.  2004; 1697: 137-142.
  • Xie Z, Tsai L-H.  Cdk5 phosphorylation of FAK regulates centrosome-associated microtubules and neuronal migration.  Cell Cycle.  2004; 3: 108-110.



  • Gupta A, Tsai L-H. Cyclin-dependent kinase 5 and neuronal migration in the neocortex. Neurosignals. 2003 Sep-Oct;12(4-5):173-9.
  • Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai LH. Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. J Neurosci. 2003 Apr 1;23(7):2769-78.
  • Samuels BA, Tsai L-H.  Cdk5 is a dynamo at the synapse.  Nat Cell Biol. 2003; 5: 689-690.
  • Lee, M-S, Tsai L-H.  Cdk5:  One of the links between senile plaques and neurofibrillary tangles? J Alzh Dis. 2003; 5:127-137.



  • Gupta A, Tsai L-H, Wynshaw-Boris A.  Life is a journey: a genetic look at neocortical development. Nat. Rev Gene, 2002; 3:342-55.
  • Patzke H, Tsai L-H.  Cdk5 sinks into ALS.  Trends Neurosci. 2002; 25:8-10.
  • Smith DS, Tsai L-H.  Cdk5 behind the wheel: a role in trafficking and transport.  Trends Cell Biol 2002; 12: 28-36.



  • Dhavan R, Tsai L-H.  A decade of Cdk5.  Nat Rev Mol Cell Biol. 2001; 2: 749-759.
  • Smith DS, Greer PL, Tsai L-H.  Cdk5 on the brain.  Cell Growth Differ 2001;12:277-283.
  • Gupta A, Tsai L-H.  A kinase to dampen the effects of cocaine?  Science 2001;292:236-237.
  • Lee M-S, Tsai L-H.  Cdk5 at the junction.  News and Views, Nat Neurosci 2001; 4: pp340-342.



  • Nikolic M, Tsai L-H.  Activity and regulation of p35/Cdk5 kinase complex. Methods Enzymol. 2000;325:200-13.
  • Kwon YT, Tsai L-H.  The role of the p35/Cdk5 kinase in cortical development. Results Probl Cell Differ. 2000;30:241-53.



  • Tsai L-H.  Stuck on the ECM. Trends Cell Biol. 1998 Jul;8(7):292-5.



  • Caviness VS Jr, Takahashi T, Miyama S, Tsai L-H.  Cytogenesis in the developing mouse neocortex. In: Brain lesions in the newborn.  Alfred Benzon Symposium 1994;37:25-42.



  • Stillman and J. Watson (eds), Cold Spring Harbor Laboratory Press.  Faha B, Meyerson M, Tsai L-H. Adenovirus E1A targets one of two cyclin A-kinase complexes.  Pezcoller Foundation Symposium 1992; 3:107-30.



  • Meyerson M, Faha B, Su LK, Harlow E, Tsai L-H. The cyclin-dependent kinase family.  In The Cell Cycle, Cold Spring Harbor Symposium on Quantitation Biology, 1991 56:177-186. D. Beach, B.