ON a black background the M-shaped coronal cross section of a mouse brain featurse patches of magenta and teal dots

With fractured genomes, Alzheimer’s neurons call for help

Study indicates that ailing neurons may instigate an inflammatory response from the brain’s microglia immune cells A new study by researchers in The Picower Institute for Learning and Memory at MIT provides evidence from both mouse models and postmortem human tissue of a direct link between two problems that emerge in Alzheimer’s disease: a buildup …

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A swirling blue ball of long thin neurons is overlaid with long electrodes coming in from the bottom and the left.

How microglia contribute to Alzheimer’s disease

A breakdown of lipid metabolism in these brain cells promotes inflammation and interferes with neuron activity, a new study finds One of the hallmarks of Alzheimer’s disease is a reduction in the firing of some neurons in the brain, which contributes to the cognitive decline that patients experience. A new study from MIT shows how …

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Boston Globe op-ed: How science, technology, and industry can work together to cure Alzheimer’s

The Alzheimer’s research community must acknowledge the gaps in the current approach to curing the disease and make significant changes. In The Boston Globe Nov. 29, Li-Huei Tsai penned an op-ed as part of Globe’s “The Longevity Hub” collaboration with MIT Professor Joe Coughlin. “Alzheimer’s disease, the sixth leading cause of death in the United States, …

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Study links gene to cognitive resilience in the elderly

The findings may help explain why some people who lead enriching lives are less prone to Alzheimer’s and age-related dementia Many people develop Alzheimer’s or other forms of dementia as they get older. However, others remain sharp well into old age, even if their brains show underlying signs of neurodegeneration. Among these cognitively resilient people, …

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A colorful cartoon of a DNA double helix with a gap through the middle

Memory making involves extensive DNA breaking

To quickly express genes needed for learning and memory, brain cells snap both strands of DNA in many more places and cell types than previously realized, a new study shows The urgency to remember a dangerous experience requires the brain to make a series of potentially dangerous moves: Neurons and other brain cells snap open …

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Li-Huei Tsai is shown in profile as she stands smiling at a podium

Li-Huei Tsai elected to American Academy of Arts & Sciences

The American Academy of Arts & Sciences announced today that Li-Huei Tsai, Picower Professor of Neuroscience and Director of The Picower Institute for Learning & Memory, is among 252 luminaries elected to join its esteemed membership. “We are honoring the excellence of these individuals, celebrating what they have achieved so far, and imagining what they …

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