2024

  • Mathys H, Boix CA, Akay LA, Xia Z, Davila-Velderrain J, Ng AP, Jiang X, Abdelhady G, Galani K, Mantero J, Band N, James BT, Babu S, Galiana-Melendez F, Louderback K, Prokopenko D, Tanzi RE, Bennett DA, Tsai L-H, Kellis M. Single-cell multiregion dissection of Alzheimer’s disease. Nature. 2024 July 24. Online ahead of print. doi.org/10.1038/s41586-024-07606-7.

  • Kim, TH, James BT, Kahn MC, Blanco-Duque C, Abdurrob F, Islam MDR, Lavoie NS, Kellis M, Tsai L-H.  Gamma entrainment using sensory stimuli alleviates chemobrain pathology and cognitive impairment induced by chemotherapy agents. Sci Trans Med. 2024 Mar 6;16(737):eadf4601.  Epub 2024 Mar 6. PMID: 38446899. doi: 10.1126/scitranslmed.adf4601.

  • Murdock MH, Yang C-Y, Sun N, Pao, P-C, Blanco-Duque, C, Kahn MC, Lavoie NS, Victor MB, Islam MR, Galia F, Leary N, Wang S, Bubnys A, Ma E, Akay LA, Kim TH, Sneve M, Qian Y, Lai C, McCarthy MM, Kopell N, Kellis M, Piatkevich KD, Boyden ES, Tsai L-H. Nature. 2024 Mar;627(8002):149-156. Epub 2024 Feb 28. PMID: 38418876. doi: 10.1038/s41586-024-07132-6.

2023

  • Ralvenius WT, Andresen JL, Huston MM, Penney J, Bonner JM, Fenton OS, Langer R, Tsai L-H. Nanoparticle-mediated delivery of anti-PU.1 siRNA via localized intracisternal administration reduces neuroinflammation. Adv Mater. 2024 Feb;36(8):e2309225. Epub 2023 Dec 8. PMID: 38018280. doi: 10.1002/adma.202309225.

  • Xiong Z, James BT, Boix CA, Park YP, Galani K, Victor MB, Sun N, Hou L, Ho L-L, Mantero J, Scannail AN, Dileep V, Dong W, Mathys H, Bennett DA, Tsai L-H, Kellis M. Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion. Cell. 2023 Sep 28;186(20):4422-4437.e21. PMID: 37774680. doi: 10.1016/j.cell.2023.08.040.

  • Dileep V, Boix CA, Mathys H, Marco A, Welch GM, Meharena HS, Loon A, Jeloka R, Peng Z, Bennett DA, Kellis M, Tsai L-H. Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration. Cell. 2023 Sep 28;186(20):4404-4421.e20. PMID: 37774679. doi: 10.1016/j.cell.2023.08.038.

  • Sun N, Victor MB, Park YP, Xiong X, Scannail AN, Leary N, Prosper P, Viswanathan S, Luna X, Boix CA, James BT, Tanigawa Y, Galani K, Mathys H, Jiang X, Ng AP, Bennett DA, Tsai L-H, Kellis M. Human microglial state dynamics in Alzheimer’s disease progression. Cell. 2023 Sep 28;186(20):4386-4403.e29. PMID: 37774678. doi: 10.1016/j.cell.2023.08.037.

  • Mathys H, Peng Z, Boix CA, Victor MB, Leary N, Babu S, Abdelhady G, Jiang X, Ng AP, Ghafari K, Kunisky AK, Mantero J, Galani K, Lohia VN, Fortier GE, Lotfi Y, Ivey J, Brown HP, Patel PR, Chakraborty N, Beaudway JI, Imhoff EJ, Keller CF, McChesney MM, Patel HH, Patel SP, Thai MT, Bennett DA, Kellis M, Tsai L-H. Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology. Cell. 2023 Sep 28;186(20):4365-4385.e27. PMID: 37774677. doi: 10.1016/j.cell.2023.08.039.

  • Ralvenius, WT, Mungenast AE, Woolf H, Huston MM, Gillingham TZ, Godin SK, Penney J, Cam HP, Gao F, Fernandez CG, Czako B, Lightfoot Y, Ray WJ, Beckmann A, Goate AM, Marcora E, Romeo-Molina C, Ayata P, Schaefer A, Gjoneska E, Tsai L-H. A novel molecular class that recruits HDAC/MECP2 co-repressor complexes to PU.1 motifs reduces neurodegeneration and inflammation. J Exp Med. 2023 Nov 6;220(11):e20222105.  Epub 2023 Aug 29. PMID: 37642942. doi: 10.1084/jem.20222105.

  • Sun N, Akay LA, Murdock MH, Park Y, Galiana-Melendez F, Bubnys A, Galani K, Mathys H, Jiang X, Ng AP, Bennett DA, Tsai L-H, Kellis M. Single-nucleus multi-region transcriptomic analysis of brain vasculature in Alzheimer’s disease. Nat Neuro. 2023. Jun;26(6):970-982. Epub 2023 Jun 1. PMID: 37264161. doi: 10.1038/s41593-023-01334-3.

  • Suk HJ, Buie N, Xu G, Banerjee A, Boyden ES, Tsai L-H. Vibrotactile stimulation at gamma frequency mitigates pathology related to neurodegeneration and improves motor function. Front Aging Neuro. May 18;15:1129510. PMID: 37273653. doi: 10.3389/fnagi.2023.1129510.

  • Huang W-C, Peng Z, Murdock MH, Liu L, Mathys H, Davila-Velderrain J, Jiang X, Chen M, Ng AP, Kim TH, Abdurrob F, Gao F, Bennett DA, Kellis M, Tsai L-H. Lateral mammillary body neurons in mouse brain are disproportionately vulnerable in Alzheimer’s disease.  Sci Trans Med. 2023. Apr 19;15(692):eabq1019. Epub 2023 Apr 19. doi: 10.1126/scitranslmed.abq1019.

  • Pao P-C, Seo J, Lee A, Kritskiy O, Patnaik D, Penney J, Raju RM, Geigenmuller U, Silva MC, Lucente DE, Gusella JF, Dickerson BC, Loon A, Yu MX, Bula M, Yu M, Haggarty SJ, Tsai L-H. A novel Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes. PNAS. 2023. Epub 2023 Apr 12. doi: 10.1073/pnas.2217864120.

2022

  • Diane Chan, Ho-Jun Suk, Brennan Leo Jackson, Noah P Milman, Danielle Stark, E.B. Klerman, Erin Kitchener, Vanesa S. Fernandez Avalos, Gabrielle de Weck, Arit Banerjee A, S.D. Beach, Joel Blanchard J, C. Stearns, A.D. Boes, B. Uitermarkt B, P. Gander P, M. Howard M, E.J. Sternberg EJ, A. Nieto-Castanon A, S. Anteraper, S. Whitfield-Gabrieli, Emery N. Brown, Edward S. Boyden, B.C. Dickerson, Li-Huei Tsai. Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies. PLoS One. 2022 Dec 1;17(12):e0278412. eCollection 2022. PMI: 36454969. https://doi.org/10.1371/journal.pone.0278412.
  • Joel W. Blanchard, Leyla Akay LA, Jose Davila-Velderrain, Djuna von Maydell, Hansruedi Mathys, S.M.Davidson, Audrey Effenberger, C-U Chen, K. Maner-Smith, I. Hajjar, E.A. Ortlund, Michael Bula, Emre Agbas, A. Ng A, Xueqiao Jiang, Martin Kahn, Cristina Blanco-Duque, Nic Lavoie, Liwang Liu, R. Reyes R, Y-T Lin, T. Ko, L. R’Bibo, William Ralvenius, D.A. Bennett, Hugh P. Cam, Manolis Kellis, Li-Huei Tsai.  APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes. Nature. 2022. Epub 2022 Nov 16. https://doi.org/10.1038/s41586-022-05439-w.
  • Gwyneth M. Welch, Carles A. Boix, E. Schmauch, Jose Davila-Velderrain, Matheus B Victor, Vishnu Dileep, P. Lorenzo Bozzelli,, Q. Su, J.D. Cheng, A. Lee, Noelle S. Leary, A.R. Pfenning, Manolis Kellis M, Li-Huei Tsai. Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration. Sci Adv. 2022 Sep 30;8(39):eabo4662. doi: 10.1126/sciadv.abo4662. Epub 2022 Sep 28.
  • Chinakkaruppan Adaikkan, J. Wang, Karim Abdelaal, S.J. Middleton, P. Lorenzo Bozzelli, Ian Wickersham I, T.J. McHugh, Li-Huei Tsai. Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration. Neuron. 2022 Oct 5;110(19):3091-3105.e9. Epub 2022 Aug 19. https://doi.org/10.1016/j.neuron.2022.07.023.
  • Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, A.N. Scannail, P. Lorenzo Bozzelli, George S. Samaan, Mitchell H. Murdock, Djuna von Maydell, Audrey H. Effenberger, Oyku Cerit, H-L Wen, Liwang Liu, Gwyneth Welch, Maeve Bonner, Li-Huei Tsai. Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity. Cell Stem Cell. 2022 Aug 4;29(8):1197-1212.e8. PMID: 35931030. https://doi.org/10.1016/j.stem.222.07.005.
  • Hiruy Meharena, Asaf Marco, Vishnu Dileep, Elana R. Lockshin, Grace Y. Akatsu, James Mullahoo, L. Ashley Watson, Tak Ko, Lindsey N. Guerin, Fatema Abdurrob, Shruthi Rengarajan, Malvina Papanastasiou, Jacob D. Jaffe, Li-Huei Tsai. Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors.
    Cell Stem Cell. 2022 Jan 6;1:116-130.e7. https://doi.org/10.1016/j.stem.2021.12.002

2021

  • Grzegorz Sienski, Priyanka Narayan, Julia Maeve Bonner, Nora Kory, Sebastian Boland, Aleksandra A. Arczewska, William T. Ralvenius, Leyla Akay, Elana Lockshin, Liang He, Blerta Milo, Agnese Graziosi, Valeriya Baru, Caroline A. Lewis, Manolis Kellis, David Sabatini, Li-Huei Tsai, APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia, Science Transl Med. Mar 3;13(583):eaaz4564. doi: 10.1126/scitranslmed.aaz4564.

2020

  • Asaf Marco, Hiruy S. Meharena, Vishnu Dileep, Ravikiran Raju, Jose Davila-Velderrain, Zhang A, Chinnakkaruppan Adaikkan, Jennie Z. Young, Fan Gao, Manolis Kellis, Li-Huei Tsai. Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble. Nat Neurosci. 2020 Dec;23(12):1606-1617. doi: 10.1038/s41593-020-00717-0.
  • Joel W. Blanchard, Michael Bula, Jose Davila-Velderrain, Leyla Anne Akay, Lena Zhu, Alexander Frank, Matheus B. Victor, Julia Maeve Bonner, Hansruedi Mathys, Yuan-Ta Lin,  Tak Ko, David A. Bennett, Hugh P. Cam, Manolis Kellis, Li-Huei Tsai, Reconstruction of the Human Blood-Brain Barrier in vitro reveals a Pathogenic Mechanism of APOE4 in Pericytes, Nature Medicine 2020 Jun;26(6):952-963. doi: 10.1038/s41591-020-0886-4.
  • Ping-Chieh Pao, Debasis Patnaik, L. Ashley Watson, Fan Gao, Ling Pan, Jun Wang, Chinnakkaruppan Adaikkan, Jay Penney, Hugh P. Cam, Wen-Chin Huang, Lorena Pantano, Audrey Lee, Alexi Nott, Trongha X. Phan, Elizabeta Gjoneska, Sara Elmsaouri, Stephen J. Haggarty, Li-Huei Tsai, HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease. Nature Commun, 2020 May 18; 11(1): 2484. doi: 10.1038/s41467-020-16361-y.

2019

  • Rebecca Gail Canter, Wen-Chin Huang, Heejin Choi, Jun Wang, Lauren Ashley Watson, Christine G. Yao, Fatema Abdurrob, Stephanie M. Bousleiman, Jennie Z. Young, David A. Bennett, Ivana Delalle, Kwanghun Chung, Li-Huei Tsai, 3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice. Commun Biol 2, 360 (2019) doi:10.1038/s42003-019-0599-8
  • Fan Q, Gayen M, Singh N, Gao F, He W, He X, Tsai L-H, Yan R. The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer’s amyloid pathology. Journal of Experimental Medicine, 2019 Jun 17. pii: jem20182238.  Doi: 10. 1084/jem.20182238.
  • Chinnakkaruppan Adaikkan, Steven J. Middleton, Asaf Marco, Ping-Chieh Pao, Hansruedi Mathys, David Nam-Woo Kim, Fan Gao, Jennie Z. Young, Ho-Jun Suk, Edward S. Boyden, Thomas J. McHugh, Li-Huei Tsai. (2019) Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection. Neuron, 7 May 2019; Doi: 10.1016/j.neuron.2019.04.011
  • Mathys, Hansruedi, Davila-Velderrain, Jose, Peng, Zhuyu, Gao, Fan, Mohammadi, Shahin, Young, Jennie Z., Menon, Madhvi, He, Liang, Abdurrob, Fatema, Jiang, Xueqiao, Martorell, Anthony J., Ransohoff, Richard M., Hafler, Brian P., Bennett, David A., Kellis, Manolis, Tsai, Li-Huei. (2019) Single-cell transcriptomic analysis of Alzheimer’s disease. Nature, 1 May 2019; Doi: 10.1038/s41586-019-1195-2
  • Anthony J. Martorell, Abigail L. Paulson, Ho-Jun Suk, Fatema Abdurrob, Gabrielle T. Drummond, Webster Guan, Jennie Z. Young, David Nam-Woo Kim, Oleg Kritskiy, Scarlett J .Barker, Vamsi Mangena, Stephanie M. Prince, Emery N. Brown, Kwanghun Chung, Edward S. Boyden, Annabelle C. Singer, Li-Huei Tsai. (2019) Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition. Cell, 4 April 2019; Volume 177, Issue 2, P256-271.e22. Doi: 10.1016/j.cell.2019.02.014
  • Amal H, Gong G, Lewis S, Wishnok J, Gjoneska E, Tsai L-H, Tennenbaum S. S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the PS301S mouse model of tauopathy. Translational Psychiatry.2019 Jan 29; 9(1): 44. Doi 10.1038/s41398-019-0388-7. PMID: 30696811.
  • Meyer K, Feldman H, Lu T, Drake D, Lim E, King-Hwa L, Bishop N, Pan Y, Seo J, Lin YT, Su S, Church G, Tsai L-H, Yankner B. REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease. Cell Reports. 26, 1-16. 2019 Jan 29; 26 (5): 1112-1127.e9. doi: 10.1016/j.celrep.2019.01.023. PMID: 30699343.
  • Klein HU, McCabe C, Gjoneska E, Sullivan SE, Tang A, Smith RV, Xu J, Pfenning AR, Bernstein BE, Meissner A, Schneider JA, Mostafavi S, Tsai LH, Young-Pearse TL, Bennett DA, De Jager PL. Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains. Nat Neurosci. 2019 Jan 22 (1): 37-46. Doi: 10.1038/s41593-018-0291-1. PMID 30559478.

2018

  • Singer A, Martorell A, Douglas JM, Abdurrob F, Attokaren M, Tipton J, Mathys H, Adaikkan C and Tsai L-H. (2018) Non-invasive 40 Hz light flicker to reduce amyloid load and recruit microglia. Nature Proto, 2 Aug 2018; 13, 1850–1868 (2018). Doi: 10.1038/s41596-018-0021-x
  • Lin YT, Seo J, Gao F, Feldman HM, Wen H, Penney J, Cam HP, Gjonetska E, Raja W, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner B and Tsai L-H. (2018). APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes across human iPSC-derived brain cell types. Neuron, 2018 Jun 27; 98 (6):1294. Doi: 10.1016/j.neuron.2018.06.011. PMID: 29953873.
  • Zhao WN, Ghosh B, Tyler M, Lalonde J, Joseph NF, Kosaric N, Fass DM, Tsai LH, Mazitschek R, Haggarty SJ. Class 1 Histone Deacetylase Inhibition by Tianetinaline Modulates Neuroplasticity and Enhances Memory. ACS Chem Neuroscience. 2018 Jun 22. doi: 10.1021/acschemneuro.8b00116.

2017

  • Matthew RS, Tatarakis A, Rudenko A, Johnson-Venkatesh EM, Yang YJ, Murphy EA, Todd TP, Schepers SP, Siuti N, Martorell A, Falls WA, Hammack SE, Walsh CA, Tsai L-H, Umemori H, Bouton ME, Moazed D. Inhibition of memory by a microRNA negative feedback loop that downregulates SNARE-mediated vesicle transport. 2016 Dec 21; 5. Pii e22467. Doi: 10.7554/eLife.22467. PMID: 28001126.
  • Shukla V, Seo J, Binukumar BK, Amin ND, Reddy P, Grant P, Kuntz S, Kesavapany S, Steiner J, Mishra SK, Tsai L-H, Pant HC. TFP5, a peptide inhibitor of aberrant and hyperactive Cdk5/p25, attenuates pathological phenotypes and restores synaptic function in CK-p25Tg mice. J Alzheimers Dis. 2017; 56(1): 335-349. Doi: 10.3233/JAD-160916. PMID: 28085018
  • Grossman N, Bono D, Dedic N, Kodandaramaiah SB, Rudenko A, Suk HJ, Cassara AM, Neufeld E, Kuster N, Tsai L-H, Pascual-Leone A, Boyden ES. Noninvasive deep brain stimulation via temporally interfering electric fields. Cell. 2017 Jun 1; 169(6): 1029-1041.e16. Doi: 10.1016/j.cell.2017.05.024. PMID: 28575667
  • Yamakawa H, Cheng J, Penney J, Gao F, Rueda R, Wang J, Yamakawa S, Kritskiy O, Gjoneska E, Tsai LH. (2017) The transcription factor Sp3 cooperates with HDAC2 to regulate synaptic function and plasticity in neurons.  Cell Reports, 2017 Aug.8;20(6):1319-1334. Doi: 10.1016/j.celrep.2017.07.044
  • Penney J, Seo J, Kritskiy O, Elmsaouri S, Pao PC, Su SC, Tsai LH. (2017) Loss of protein arginine methyltransferase 8 alters synapse composition and function, resulting in behavioral defects. Journal of Neuroscience, 3 August 2017, 0591-17.  DOI: 10.1523/JNEUROSCI.0591-17.2017
  • Seo J, Kritskiy O, Watson LA, Barker S, Dey D, Raja W, Lin Y, Ko T, Cho S, Penney J, Silva MC, Sheridan S, Lucente D, Gusella J, Dickerson B, Haggarty S, Tsai LH. (2017) Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia. J Neurosci. 2017 Oct 11;37(41):9917-9924. Doi: 10.1523/JNEUROSCI.0621-17.2017. Epub 2017 Sep 14.
  • Mathys H, Adaikkan C, Gao F, Young JZ, Manet E, Hemberg M, De Jager PL, Ransohoff RM, Regev A, Tsai LH. (2017) Temporal tracking of microglia activation in neurodegeneration of single-cell resolution. Cell Rep. 2017 Oct 10; 21 (2): 366-380. Doi. 10.1016/j.celrep.2017.09.039.201

2016

      • Nott A, Cheng J, Gao F, Lin YT, Gjoneska E, Ko T, Minhas P, Zamudio AV, Meng J, Zhang F, Jin P, Tsai L-H. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. Nat Neurosci. 2016 Jul 18. doi: 10.1038/nn.4347. PMID: 27428650.
      • Raja WK, Mungenast AE, Lin YT, Ko T, Abdurrob F, Seo JS, Tsai L-H. Self-organizing 3D human neural tissue derived from induced pluripotent stem cells recapitulate Alzheimer’s disease phenotypes. PLosOne. 2016 Sept 13; 11 (9): e0161969. Doi: 10.1371/journal.pone.0161969.ecollection 2016. PMID: 27622770.
      • Durak O, Gao F, Tsai L-H. Chd8 mediates cortical neurogenesis through transcriptional regulation of cell cycle and Wnt signaling genes. Nat Neurosci. 2016 Oct 3. Doi: 10/10138/nn.4400. [Epub ahead of print]. PMID: 27694995.
      • Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai L-H. (2016). Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 2016 Dec 7; 540 (7632): 230-235. Doi: 10.1038/nature20587. PMID: 27929004.

2015

      • Nott A, Cho S, Seo J, Tsai L-H. HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex. Neuroepigenetics. 2015 Jan 1; 1: 34-40. https://doi.org/10.1016/j.nepig.2014.10.005.  PMID: 25705589.
      • Rudenko A, Seo J, Hu J, Su S, de Anda FC, Durak O, Ericcson M, Carlen M, Tsai L-H. Loss of Cdk5 from Parvalbumin-interneurons leads to hyperinhibition, decreased anxiety and memory impairment. J Neurosci. 2015 Feb 11; 35 (6): 2372-83. doi: 10.1523/JNEUROSCI.0969-14.2015. PMID: 25673832.
      • Gjoneska E, Pfenning A, Mathys H, Quon G, Kundage A, Tsai LH**, Kellis M**, Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease. Nature 2015 Feb 18; doi: 10.1038/nature14252. (**Co-Contributing Authors).
      • Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast A, Tsai LH. The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nat Neurosci 2015 Jul;18(7):1008-16. doi: 10.1038/nn.4023. Epub 2015 May 25. PMID: 26005852.
      • Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH. Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes. Cell 2015 Jun 18;161(7):1592-605. doi: 10.1016/j.cell.2015.05.032. Epub 2015 Jun 4. PMID: 26052046.

2014

      • Gräff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, Rei D, Bero AW, Phan TX, Wagner F, Holson E, Xu J, Sun, J, Neve RL, Mach RH, Haggarty SJ, Tsai LH. Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 2014 Jan 16;156(1-2):261-76. doi: 10.1016/j.cell.2013.12.020. PMID: 24439381.
      • Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Molecular Psychiatry. 2014 Nov doi: 10.1038/mp.2014.143 PMID: 25403839.
      • Seo J, Giusti-Rodríguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madabhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH. Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment. Cell 2014 Apr 10;157(2):486-98.doi:10.10.16/j.cell.2014.01.065. PMID:24725413.
      • Durak O, de Anda FC, Singh KK, Leussis MP, Petryshen TL, Sklar P, Tsai LH. Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin. Mol Psychiatry. 2014 May 13 doi: 10.1038/mp.2014.42. [Epub ahead of print]. PMID:24821222.
      • Rudenko A, Tsai LH. Epigenetic modifications in the nervous system and their impact upon cognitive impairments. Neuropharmacology. 2014 May; 80:70-82. doi: 10.1016/j.neuropharm.2014.01.043. Epub 2014 Feb 1. PMID:24495398.
      • Tsai LH, Madabhushi R. Alzheimer’s disease: A protective factor for the aging brain. Nature 2014 Mar 27;507(7493):439-40. doi: 10.1038/nature13214. PMID: 24670758.

2013

      • Rudenko A, Dawlaty M, Seo J, Cheng A, Meng  J, Le T, Faull K, Jaenisch R, Tsai LH. Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction. Neuron 79.6 (2013): 1109-1122. ScienceDirect. Web. 18 Sept. 2013. 10.1016/j.neuron.2013.08.003
      • Wang W, Pan L, Su S, Quinn E, Sasaki M, Jimenez J, Mackenzie I, Huang E, Tsai LH. Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons. Nature 2013 September 15; doi:10.1038/nn.3514(Online).

2012

      • Gräff J, Rei D, Guan J, Wang W, Seo J, Henning K, Nieland T, Fass D, Kao P, Kahn M, Su S, Samiei A, Joseph N, Haggarty S, Delalle I, Tsai LH. An epigenetic blockade of cognitive functions in the neurodegeneration brain. Nature 2012 Feb 29;483(7388):222-6. doi: 10.1038/nature10849 (PMC Journal- In Process).
      • Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH. Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Epigenetics. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(7):741-6.10.1093/gerona/gls110. (PMC Journal- In Process).
      • Calderon F, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabushi R, Ginty DD, Kolodkin AL, and Tsai LH. An Autism Spectrum Disorder Susceptibility Gene, TAO2, is Important for Basal Dendrite Formation in the Neocortex. Nat Neurosci 2012 Jun 10;15(7):1022-31. doi: 10.1038/nn.3141. (PMC Journal- In Process).
      • Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Groves Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.Neuropharmacology. 2012 Jul 4. 10.1016/j.neuropharm.2012.06.043 (In Press) (PMC Journal- In Process).
      • Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH. Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron 2012 Aug 23;75(4):675-87. 10.1016/j.neuron.2012.06.023. (PMC Journal- In Process).
      • Zhao WN, Cheng C, Theriault KM, Sheridan SD, Tsai LH, Haggarty SJ. A High-Throughput Screen for Wnt/β-Catenin Signaling Pathway Modulators in Human iPSC-Derived Neural Progenitors. J Biomol Screen. 2012 Aug 24.10.1177/1087057112456876 (In Press) (PMC Journal- In Process).

2011

      • Siegle JH, Carlen M, Meletis K, Tsai LH, Moore CI, Ritt J. Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:7529-32.10.1109/IEMBS.2011.6091856. PMCID: PMC 22256080.
      • Carlen M, Meletis K, Siegle JH, Cardin JA, Futai K, Vierling-Claassen D, Ruhlmann C, Jones SR, Deisseroth K, Sheng M, Moore CI, Tsai LH. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior.Mol Psychiatry. 2012 May;17(5):537-48. doi: 10.1038/mp.2011.31. PMCID: PMC3335079.
      • Pinheiro EM, Xie Z, Norovich AL, Vidaki M, Tsai LH, Gertler FB. Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons. Nat Cell Biol. 2011 Jul 24;13(8):989-95. doi: 10.1038/ncb2292. PMCID: PMC3149714.
      • Buchman JJ, Durak O, Tsai LH. ASPM regulates Wnt signaling pathway activity in the developing brain.Genes Dev. 2011 Sep 15;25(18):1909-14. doi: 10.1101/gad.16830211. PMCID: PMC3185963.
      • Guan JS, Su SC, Gao J, Joseph N, Xie Z, Zhou Y, Durak O, Zhang L, Zhu JJ, Clauser KR, Carr S, Tsai LH. Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. PLos One 6(9): e25735. doi:10.1371/journal.pone.0025735 PMCID: PMC3184170.
      • Giusti-Rodríguez P, Gao J, Gräff J, Rei D, Soda T, Tsai LH. Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of beta-secretase (BACE1). J Neurosci. 2011 Nov 2;31(44):15751-6. 10.1523/JNEUROSCI.3588-11.2011. PMCID: PMC3248793.
      • Kim J, Su SC, Wang H, Cheng AW, Cassady JP, Lodato MA, Lengner CJ, Chung C-Y, Dawlaty MM, Tsai LH, Jaenisch R. Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts. Cell Stem Cell. 2011 Nov 4;9(5):413-9.doi:10.1016/j.stem.2011.09.011. PMCID: PMC3210333.
      • Singh KK, DiRienzo G, Drane L, Mao Y, Flood Z, Madison J, Ferreira M, Bergen S, King C, Sklar P, Sive H, Tsai LH. Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development. Neuron. 2011 Nov 17;72(4):545-58. https://doi.org/10.1016/j.neuron.2011.09.030. PMCID: PMC3387684.
      • Kwon E, Wang W, Tsai LH. Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C, and TCF4 as miR-137 targets. Mol Psychiatry. 2011 Dec 20. doi: 10.1038/mp.2011.170 (PMC Journal- In Process).

2010

      • Ge X, Frank CL, Calderon F, Tsai LH.  Hook3 interacts with PCM1 to regulate the pericentriolar material assembly and the timing of neurogenesis. Neuron, 2010.  Jan 28;65(2):191-203. 10.1016/j.neuron.2010.01.011. PMCID: PMC2902371.
      • Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI.  Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2.  Nat Protoc. 2010 Feb;5(2):247-54. doi:10.1038/nprot.2009.228 (PMC Journal- In Process).
      • Buchman JJ, Tseng HC, Zhou Y, Frank CL, Xie Z, and Tsai LH. Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex. Neuron, 2010 May;66: 386-402. 10.1016/j.neuron.2010.03.036. (PMC Journal- In Process).
      • Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J.  Negative regulation of Vps34 by Cdk mediated phosphorylation.  Mol Cell.  2010.  May 28;38(4):500-511. 10.1016/j.molcel.2010.05.009. PMCID: PMC2888511.
      • Gao J, Wang WY, Mao YW, Gräff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai LH.  A novel pathway regulates memory and plasticity via SIRT1 and miR-134.  Nature. 2010 Aug.  26;466(7310):1105-9. https://doi.org/10.1038/nature09271. PMCID: PMC2928875.
      • Singh KK, Ge X, Mao Y, Drane L, Meletis K, Samuels BA, Tsai LH.  Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.  Neuron. 2010 Jul 15;67(1):33-48. 10.1016/j.neuron.2010.06.002. PMCID: PMC2938013.
      • De Anda CF, Meletis K, Ge X, Rei D, Tsai LH.  Centrosome motility is essential for initial axon formation in the neocortex.   J Neurosci 2010 Aug 4;30(31):10391-406.10.1523/JNEUROSCI.0381-10.2010. (PMC Journal- In Process).
      • Frank CL, Ge X, Xie Z, Zhou Y, Tsai LH.  Control of ATF4 persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. J Biol Chem. 2010 Oct 22;285(43):33324-37. 10.1074/jbc.M110.140699. PMCID: PMC2963346.
      • Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW.  Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.  Proc Natl Acad Sci USA. 2010 Dec 14;107(50):21790-4. 10.1073/pnas.1016306107. PMCID: PMC3003110.

2009

      • Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH.  Disrupted in Schizophrenia 1 regulates neural progenitor proliferation via modulation of GSK3/-catenin signaling. Cell, 2009, Mar 20; 136(6): 1017-3. 10.1016/j.cell.2008.12.044. PMCID: PMC2704382.
      • Guan J-S, Haggarty SJ, Giacometti E, Dannenberg J-H, Joseph N, Gao J, Nieland TJF, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai, LH. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature, 2009 May 7; 459(7243): 55-60. 10.1038/nature07925. (PMC Journal- In Process).
      • Cardin JA, Carlen M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI.  Driving fast-spiking cells induces gamma rhythm and controls. sensory responses.  Nature, 2009 Jun 4; 459(7247): 663-7. 10.1038/nature08002. (PMC Journal- In Process).
      • Orlando LR, Ayala R, Kett LR, Curley AA, Duffner J, Bragg DC, Tsai LH, Dunah AW, Young AB. Phosphorylation of the homer-binding domain of group I metabotropic glutemate receptors by cyclin-dependent kinase 5.  J Neurochem. 2009 Jul;110(2):557-69. 10.1111/j.1471-4159.2009.06139.x (PMC Journal- In Process).
      • Davis DA, Wilson MH, Giraud J, Xie Z, Tseng HC, England C, Herscovitz H, Tsai LH, Delalle I. Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. PLoS Biol. 2009 Oct;7(10):e1000208. https://doi.org/10.1371/journal.pbio.1000208. PMCID: PMC2748697.

2008

      • Calderon de Anda F, Gartner A, Tsai LH, Dotti, C. Pyramidal neuron polarity axis is defined at the bipolar stage.  J Cell Sci, 2008 Jan 15;121(Pt 2):178-85. doi: 10.1242/jcs.023143
      • Shim SY, Samuels BA, Wang J, Neumayer G, Belzil C, Ayala R, Shi Y, Shi Y, Tsai LH, Nguyen MD. Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth. J Biol Chem. 2008. May 2;283(18):12232-40. 10.1074/jbc.M710200200. (PMC Journal- In Process).
      • Kim D, Frank C, Dobbin M, Tsunemoto R, Wu D, Peng P, Guan J, Lee B-H, Moy L, Gusti P, Broodie N, Mazitschek R, Delalle I, Haggarty S, Neve R, Lu Y, and Tsai LH. Deregulation of HDAC1 by p25/Cdk5 in neurodegeneration. Neuron, 2008, 60: 803-817. 10.1016/j.neuron.2008.10.015. PMCID: PMC2912147.
      • Meyer DA, Richer E, Benkovic SA, Hayashi K, Kansy JW, Hale CF, Moy LY, Kim Y, O’Callaghan JP, Tsai LH, Greengard P, Nairn AC, Cowan CW, Miller DB, Antich P, Bibb JA. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18561-6. doi: 10.1073/pnas.0806078105. PMCID: PMC2587606.

2007

      • Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai, LH.  Recovery of learning and memory is associated with chromatin remodeling.  Nature 2007, 447: 178-182. 10.1038/nature05772.
      • Yip YP, Capriotti C, Drill E, Tsai LH, Yip J. Cdk5 Selectively Affects the Migration of Different Populations of Neurons in the Developing Spinal Cord. J Comp Neurol. 2007;503(2):297-307. 10.1002/cne.21377.
      • Kim D, Nguyen MD, Fischer A, Sananbenesi F, Dobbin MM, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigsrver P, Sinclair DA, Tsai LH.  SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis.  EMBO J 2007, 26: 3169-3179. 10.1038/sj.emboj.7601758.
      • Sananbenesi F, Fischer A, Schrick C, Neve R, Radulovic J, Tsai LH. A Hippocampal Cdk5 Pathway Regulates Extinction of Contextual Fear.  Nat Neurosci. 2007, 10(8): 1012-9. 10.1038/nn1943.
      • Choe EA, Liao L, Zhou JY, Cheng D, Duong DM, Jin P, Tsai LH, Peng J. Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. J Neurosci. 2007, 27(35): 9503-12. 10.1523/JNEUROSCI.1408-07.2007.
      • Xie Z, Moy L, Sanada K, Zhou Y, Buchman J, Tsai LH. Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neural Progenitor Pool. Neuron 2007, 56: 79-93. 10.1016/j.neuron.2007.08.026.
      • Samuels, BA, Hsueh Y-P, Shu T, Liang H, Tseng H-C, Hong C-J, Su SC, Neve R, Yue, DT, Tsai, LH.  Cdk5 promotes synapse formation by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 2007, 56: 823-837. doi: 10.1016/j.neuron.2007.09.035

2006

      • ShuT., TsengH.C., ZhouY., FischerA., SternP., CoquelleF., ReinerO., Tsai L-H. Doublecortin-like Kinase Controls Neurogenesis by Regulating the Mitotic Spindle. Neuron 2006, 49:25-39. 10.1016/j.neuron.2005.10.039.
      • Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai, L-H.  p25/Cdk5 induces production and intraneuronal accumulation of amyloid beta in vivo.  J Neurosci 2006, 26: 10536-41. 10.1523/JNEUROSCI.3133-06.2006.

2005

      • Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A.  Mechanism of Cdk5/p25 binding by Cdk inhibitors.  J Med Chem. 2005, 48(3): 671-9. 10.1021/jm049323m.
      • Sanada K, Tsai LH.  G protein beta/gamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors.  Cell 2005, 122: 119-131. 10.1016/j.cell.2005.05.009.
      • Tseng H-C, Ovaa H, Wei N, Ploegh H, Tsai LH.  Phosphoproteomic analysis with a solid-phase capture-release-tag approach.  Chemistry and Biology 2005, 12: 769-777. 10.1016/j.chembiol.2005.05.012.
      • Park, SK, Nguyen MD, Fischer A, Luke MP, Affar EB, Dieffenbach, PB, Tseng HC, Shi Y, Tsai LH.  Par4 links dopamine signaling and depression.  Cell 2005, 122: 275-287. 10.1016/j.cell.2005.05.031.
      • Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai LH.  Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.  Neuron, 2005, 48: 825-838. 10.1016/j.neuron.2005.10.033.

2004

      • Kao SC, Krichevsky AM, Kosic K, Tsai, LH. BACE1 suppression by RNA interference in primary cortical neurons.   J Biol Chem 2004, 279: 1942-1949. 10.1074/jbc.M309219200.
      • Hammond V, Tsai LH, Tan SS.  Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35.  J Neurosci. 2004, 24: 576-87. 10.1523/JNEUROSCI.4529-03.2004.
      • Tanaka T, Serneo FF, Tseng H-C, Kulkarni AB, Tsai LH, Gleeson JG.  Cdk5 phosphorylation of doublecortin Ser297 regulates its effect on neuronal migration. Neuron 2004, 41:215-227. 14741103.
      • Morabito MA, Sheng M, Tsai LH.  The cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD95 in neurons.   J Neurosci 2004, 24: 865-876. 10.1523/JNEUROSCI.4582-03.2004.
      • Beffert U, Weeber E, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J.  Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.  J Neurosci2004, 24: 1897-1906. 10.1523/JNEUROSCI.4084-03.2004.
      • Sanada K, Gupta A, Tsai LH.  Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis.  Neuron 2004, 22: 197-211. 15091337.
      • Nguyen MD, Shu T, Sanada K, Lariviere RC, Tseng,HC, Park SK, Julien JP, Tsai LH.  A NUDEL dependent mechanism of Neurofilament assembly regulates the integrity of CNS neurons. Nat Cell Biol 2004, 6: 597-608. 10.1038/ncb1139.
      • Shu T, Ayala R, Nguyen MD, Xie Z, Gleeson JG, Tsai LH.  Ndel1 operates in a common pathway with Lis1 and cytoplasmic dynein to regulate cortical neuronal positioning.  Neuron 2004, 44: 263-277. 10.1016/j.neuron.2004.09.030.
      • Moy LY, Tsai LH.  Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability. J Biol Chem. 2004;279(52):54487-93. 10.1074/jbc.M406636200.
      • Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A.  Coupling PAF signaling to dynein regulation; structure of Lis1 in complex with PAF-acetylhydrolase.  Neuron  2004, 809-821. 10.1016/j.neuron.2004.11.019.

2003

      • Patzke, H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai LH.  Partial rescue of the p35-/- brain phenotype by low expression of a NSE p25-transgene.  J Neurosci 2003; 23(7):2769. 10.1523/JNEUROSCI.23-07-02769.2003.
      • Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune, S, Wynshaw-Boris A. 14-3-3 epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet. 2003; 34: 274-85. 10.1038/ng1169.
      • Xie Z, Sanada K, Samuels B, Shih H, Tsai LH. Serine 732 Phosphorylation of FAK by Cdk5 is Important for Microtubule Organization, Nuclear Movement and Neuronal Migration. Cell 2003;114: 469-482. 12941275.
      • Lee M-S, Kao S-c, Lemere CA, Xia W, Tseng H-C, Zhou Y, Neve R, Ahlijanian MK, Tsai LH. APP Processing is Regulated by Cytoplasmic Phosphorylation.  J Cell Biol 2003, 163:83-95. 10.1083/jcb.200301115.
      • Cruz JC, Tseng H-C, Goldman JA, Shih H, Tsai LH. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 2003, 40:471-483. 14642273.
      • Gupta A, Sanada K, Miyamoto DT, Rovelstad S, Pearlman AL, Brunstrom J, Tsai LH.  The layering defect in p35 deficiency is linked to radial migration with improper neuronal-glial interaction.  Nat Neurosci 2003, 6: 1284-1291. 10.1038/nn1151.

2002

      • Ross S, Tienhaara A, Lee MS, Tsai L-H, Gill G.  GC-box binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35.  J Biol Chem 2002; 277: 4455-4464. 10.1074/jbc.M110771200.
      • Patzke H, Tsai L-H.  Calpain-mediated cleavage of the Cyclin-dependent kinase-5 activator p39 to p29.  J BIol Chem 2002; 277: 8054-8060. 10.1074/jbc.M109645200.
      • Tseng HC, Zhou Y, Shen, Tsai LH.  A survey of Cdk5 activator p35 and p25 levels in Alzheimer’s disease brains.  FEBS Lett 2002; 523: 58-62. 12123804.
      • Dhavan R, Greer PL, Morabito MA, Orlando LR, and Tsai L-H. The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the -Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and -Actinin-1 in a Calcium-Dependent Manner.  J Neurosci 2002;22(18):7879-7891. 10.1073/pnas.0510405103.
      • Augustinack JC, Sanders JL, Tsai LH, Hyman BT. Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles.J Neuropathol Exp Neurol. 2002 Jun;61(6):557-64. 12071639.

2001

      • Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai LH, De Camilli P.  Amphiphysin 1 Binds the Cyclin-dependent Kinase (cdk) 5 Regulatory Subunit p35 and Is Phosphorylated by Cdk5 and cdc2.  J Biol Chem2001;276: 8104-10. 10.1074/jbc.M008932200.
      • Wenzel HJ, Robbins CA, Tsai LH, Schwartzkroin PA.  Abnormal morphological and functional organization of the hippocampus in a p35 mutant model of cortical dysplasia associated with spontaneous seizures.  J Neurosci 2001;21(3):983-98. 11157084.
      • Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH.  p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.  J Neurosci. 2001, 21: 6758-71.  11517264.
      • Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH*, Musacchio A*.  Structure and regulation of the CDK5-p25 (nck5a) complex. Mol Cell 2001, 8: 657-69.  *Contributed equally. 11583627.

2000

      • Kwon YT, Gupta A, Zhou Y, Nikolic M, Tsai LH.  Regulation of the N-cadherin-mediated adhesion by the p35/Cdk5 kinase.  Curr Biol 2000;10:363-72. doi: 10.1016/S0960-9822(00)00411-5.
      • Meijer L, Thunnissen AM, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chem Biol. 2000 Jan;7(1):51-63. 10662688.
      • Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH. Neurotoxicity induces cleavage of p35 to p25 by calpain.  Nature 2000;405: 360-64. 10.1038/35012636.
      • Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Lanier LM, Gertler FB, Vidal M, Van Etten RA, Tsai L-H.  Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron 2000;26: 633-46. 10896159.
      • Humbert S, Lanier LM, Tsai LH.  Synaptic localization of p39, a neuronal activator of Cdk5. Neuroreport2000;11: 2213-16. 10923673.
      • Smith DS, Niethammer M, Ayala R, Zhou Y, Gambello MJ, Wynshaw-Boris A, Tsai LH.  Regulation of cytoplasmic dynein behavior and microtubule organization by mammalian Lis1.  Nat Cell Biol 2000;2:767-75. 10.1038/35041000.
      • Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH.  Nudel is a novel Cdk5 substrate that associates with Lis1 and cytoplasmic dynein.  Neuron 2000; 28: 697-711. 11163260.

1999

      • Philpott A, Tsai LH, Kirschner MW.  Neuronal differentiation and patterning in Xenopus:  the role of Cdk5 and a novel activator Xp35.2.  Dev. Biol 1999;207:119-32. 10049569.
      • Delalle I, Takahashi T, Nowakowski RS, Tsai LH, Caviness VS Jr.  Cyclin E – p27 opposition and regulation of the G1 phase of the cell cycle in the murine neocortical PVE:  A quantitative analysis of mRNA in situ hybridization.  Cerebral Cortex 1999;9:824-32. 10601001.
      • Huang D, Patrick G, Moffat J, Tsai LH, Andrews B.  Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase.  Pro. Natl. Acad. Sci. USA 1999;96:14445-450. 10588725.
      • Bibb JA, Synder GL, Nishi A, Zhen Y, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC Jr, Nairn AC, Greengard P.  Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signaling in neurons.   Nature 1999;402: 669-71. 10.1038/45251.
      • Kwon YT, Tsai LH, Crandall JE.  Callosal axon guidance defects in p35-/- mice.  J Comp Neurol 1999;415: 218-29. 10545161.
      • Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH.  Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.  Nature 1999;402:615-22. 10.1038/45159.
      • Humbert S, Dhavan R, Tsai LH.  p39 activates Cdk5 in neurons, and is associated with the actin cytoskeleton.  J Cell Sci 1999;113: 975-83. 10683146.

1998

      • Kwon YT, Tsai LH.  A novel disruption of cortical development in p35-/- mice distinct from reeler.  J Comp. Neurol 1998;395:510-22. 9619503.
      • Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai LH.  p35, the neuronal specific activator of Cdk5, is degraded by the ubiquitin-proteasome pathway.  J Biol Chem 1998;273:24057-63. 9727024.
      • Nikolic M, Chou MM, Lu W, Mayer BJ, Tsai LH.  The p35/Cdk5 kinase is a neuronal specific Rac effector that inhibits Pak1 activity.  Nature 1998;395:194-98. 10.1038/26034.

1997

      • Chae T, Kwon YT, Bronson R, Dikkes P, Li E, Tsai LH.  Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures and adult lethality.  Neuron 1997;18, 29-42. 9010203.
      • Delalle I, Bhide PG, Caviness VS Jr, Tsai LH.  Temporal and spatial patterns of expression of p35, a regulator subunit of cyclin-dependent kinase 5, in the nervous system of the mouse.  J Neurocytol 1997;26:283-396. 9192293.
      • Philpott A, Porro EB, Kirschner MK, Tsai LH.  The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning.  Genes and Devel 1997;11:1409-21. 9192869.

1996

      • Lee MH, Nikolic M, Baptista CA, Lai E, Tsai LH, Massague J.  The brain-specific activator p35 allows Cdk5 to escape inhibition by p27kip1 in neurons.  Pro Natl Acad Sci USA 1996;93: 3259-63. 8622924.
      • Guidato S, Tsai LH, Woodgett J, Miller CC.  Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5.  J Neurochem 1996;66:1698-706. 8627328.
      • Nikolic M, Dudek H, Kwon YT, Ramos YFM, Tsai LH.  The Cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.  Genes and Devel 1996;8:816-25. 8846918.
      • Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM.  A syndrome of multi-organ hyperplasia with features of gigantism, tumorigenesis and female sterility in p27Kip1-deficient mice.  Cell 1996;85: 733-44. 8646781.
      • Songyang Z, Lu KP, Kwon YT,Tsai LH, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves DJ, Demaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC.  A structural basis for substrate specificities of protein ser/thr kinases-primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, Cdk5 and ERK1.  Mol Cell Biol 1996;16:6486-93. 8887677

1995

      • Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E, Fox MP, Wei N. Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell 1995;6: 387-400. 7626805.
      • Missero C, Calautti E, Eckner R, Chin J, Tsai LH, Livingston DM, Dotto GP. Involvement of the cell cycle inhibitor Cip1/WAF1 and the transcriptional modulator p300 in terminal differentiation. Pro Natl Acad Sci USA 1995;92: 5451-55. 7777529.

1994

      • Tsai LH, White L, Raines E, Ross R, Smith RG, Cushley W, Ozanne B.  Expression of platelet-derived growth factor and its receptors by two pre-B acute lymphocytic leukemia cell lines.  Blood 1994:83: 51-5. 8274753.
      • Tsai LH, Delalle I, Caviness V, Chae T, Harlow E.  p35, a neural specific regulatory subunit of the Cdk5 kinase.  Nature 1994;371: 419-23. 8090221.

1993

      • Tsai LH, Lees E, Faha B, Harlow E, Riabowol K.  The cdk2 kinase is required for the G1-to-S phase transition in mammalian cells.  Oncogene 1993;8:1593-1602. 8502482.
      • Tsai LH, Takahashi T, Caviness V, Harlow E.  Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.  Development 1993;119: 1029-40. 8306873.

1992

      • Faha B, Ewen M, Tsai LH, Livingston D, Harlow E.  Interaction between human cyclin A and adenovirus E1A-associated p107 protein.  Science 1992;255:87-90. 10.1126/science.1532458.
      • Meyerson M, Enders G, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH.  A family of human cdc2-related protein kinases.  EMBO J 1992;11:2909-17. 1639063.
      • Cao L, Faha B, Dembski M, Tsai LH, Harlow E, Dyson N.  Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.  Nature 1992;355:176-179. DOI: 10.1038/355176a0

1991

      • Tsai LH, Harlow E, Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature 1991;353:174-77. 10.1038/353174a0.

1990

      • Chen Q, Cheng JT, Tsai LH, Scheneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J 1990 ;9:415-24. 2303035.
      • Tsai LH, Nanu L, Smith RG, Ozanne B. Overexpression of c-fos in a human pre-B cell acute lymphocytic leukemia derived cell line, SMS-SB. Oncogene 1990;6:81-8. 1704120.

1988

    • Tsai LH, Collins MT, Hoiby N. Antigenic analysis of Pasteurella haemolytics serovars 1 through 15 by crossed immuoelectrophoresis. Am J Vet Res 1988;49:213-22. 2450496.