As a Ph.D. student in Dr. Gabrielle Boulianne’s lab at the University of Toronto, I used Drosophila melanogaster to study a previously uncharacterized modifier of the γ-secretase complex, with potential implications for development and neurodegeneration. I further explored the molecular underpinnings of proteins associated with neurodegeneration in the lab of the late Dr. Susan Lindquist, using yeast to screen for genetic and chemical perturbations, as well as characterizing critical endocytic disruptions. Since joining the laboratory of Dr. Li-Huei Tsai, I have had the opportunity to continue pursuing research into Alzheimer’s disease-relevant proteins and pathways, focusing on the most common Alzheimer’s disease risk allele, APOE4. Using a combination of human iPSC technologies and knock-in mouse models, I am exploring the disruptions to lipid homeostasis and endocytosis induced by APOE4.
Julia “Maeve” Maeve Bonner